| 摘要 |
A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and, optionally, vinyl monomers, to from a backbone polymer, to which are grafted polymeric moieties that do not absorb greater than 3 percent by weight of a skin-penetration enhancer under thermodynamic equilibrium at 25 degree C if independently introduced into an excess of the enhancer. Preferably, the grafted polymers are selected from the classes of polybutylene, polysaccharide, the specific enhancers used in a particular poly(ethyleneoxide/propyleneoxide), and polyamide polymers, and specific grafted polymers will depend on drug delivery system.
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