| 摘要 |
<p>A group of 2-amino-3-aroyl-benzo['beta']thiophenes are prepared by preparing an 'alpha'-hydroxy thioacetamide by silyl mediated condensation of an aldehyde with an anion of dialkylamino thioformamide, cyclizing the 'alpha'-hydroxy thioamide, and subsequently acylating the benzo['beta']thiophene to yield the 2-amino-3-aryl derivative. These compounds may be treated with suitable phenyl Grignard reagents, and after deprotection, yield 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo['be ta']thiophene.</p> |
