| 发明名称 |
A strain of streptomyces lavendofoliae dkrs & a method for producing aclacinomycins a,b,y & aglycone by using the same |
| 摘要 |
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively. |
| 申请公布号 |
GB2281563(B) |
申请公布日期 |
1998.01.28 |
| 申请号 |
GB19940000513 |
申请日期 |
1994.01.12 |
| 申请人 |
* DONGKOOK PHARMACEUTICAL COMPANY LIMITED;KI BEOM * KWON |
发明人 |
WAN SEOP * KIM;MYUNG KUK * KIM;JIN KYU * PARK;HAK RYUL * KIM;SANG KI * RHEE;ALLA GEORGIEVNA * DOMRACHEVA;TATINA BAYANOVNA * PANICHKINA;LILIA ALEXANDROVNA * SABUROBA;LUDMILA MICHAILOVNA * NOBIKOBA;YURI EDUADOVICH * BARTOCHEVICHI;WON TAE * CHO |
| 分类号 |
A61K31/65;A61K31/655;A61P35/00;C12N1/20;C12N15/00;C12N15/09;C12P15/00;C12P19/56;C12P19/58;C12P19/60;C12R1/465;(IPC1-7):C12P19/56;C12P29/00 |
主分类号 |
A61K31/65 |
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