| 摘要 |
<p>A member of the heregulin superfamily has been identified which is designated 'η-HRG'. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. η-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of η-HRG nucleic acid for the recombinant production of η-HRG). η-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.</p> |
