发明名称 Iodinated derivatives, their preparation and their use as contrast agents in x-ray radiology
摘要 PCT No. PCT/FR95/01213 Sec. 371 Date May 21, 1996 Sec. 102(e) Date May 21, 1996 PCT Filed Sep. 20, 1995 PCT Pub. No. WO96/09281 PCT Pub. Date Mar. 28, 1996Polyiodinated derivatives of formula: <IMAGE> in which A is a moiety from an aromatic or aliphatic molecule, Za, Zb, Zc and Zd is Tz-Qz-Vz wherein Tz and Vz are O, COND or NDCO, and D is H or C1 to C6 alkyl or hydroxyalkyl and Qz is C1 to C6 alkylene or hydroxyalkylene or wherein Vz has the above meanings and Qz and/or Tz do not exist, Xa, Xb, Xc and Xd, which are identical or different, have formula <IMAGE> II in which Ar and Ar' are tri- or tetraiodinated phenyl groups carrying one or two amide groups substituted by optionally hydroxylated alkyls and T, Q and V have one of the meanings of the Tz, Qz and Vz, or X have, formula e formula II and the T, Q and V groups have one of the meanings of the Tz, Qz and Vz. Use of these products as contrast agents in X-ray radiology.
申请公布号 US5709846(A) 申请公布日期 1998.01.20
申请号 US19960648168 申请日期 1996.05.21
申请人 GUERBET S.A. 发明人 LEM, GAEL LE;MEYER, DOMINIQUE
分类号 A61K49/04;C07C231/02;C07C237/46;(IPC1-7):A61K49/04;C07C233/65 主分类号 A61K49/04
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