发明名称 |
METHOD FOR THE PRODUCTION OF POLYPEPTIDES |
摘要 |
The present invention relates to a novel method for the production of short chain polypeptides, including polypeptides having up to 3 disulfide bonds and/or structures rich in basic amino acid residues, and open structured short chain polypeptides, e.g. glucagon, glucagon like peptides and their functional analogues, in genetically modified yeast cells having reduced activity of YAP3 protease. The invention further comprises genetically modified yeast cells, and a method for the preparation of said yeast cells.
|
申请公布号 |
WO9801535(A1) |
申请公布日期 |
1998.01.15 |
申请号 |
WO1997DK00298 |
申请日期 |
1997.07.04 |
申请人 |
NOVO NORDISK A/S;EGEL-MITANI, MICHI;BRANDT, JAKOB;VAD, KNUD |
发明人 |
EGEL-MITANI, MICHI;BRANDT, JAKOB;VAD, KNUD |
分类号 |
C12N15/09;C07K14/475;C07K14/575;C07K14/605;C12N1/19;C12N15/81;C12P21/02;C12R1/865;(IPC1-7):C12N1/19 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|