摘要 |
<p>Solid dispersions or solid dispersion preparations containing tricyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof and a process for producing the same; wherein R?1, R2, R3 and R4¿ are the same or different and each represents hydrogen, lower alkyl, lower alkoxy, lower alkylthio, amino, lower alkylamino, halogenated lower alkyl, halogenated lower alkoxy, halogeno, nitro, cyano, carboxy, lower alkoxycarbonyl, hydroxymethyl, CR9R10CO2R11 (wherein R?9, R10 and R11¿ are the same or different and each represents hydrogen or lower alkyl) or CONR12R13 (wherein R?12 and R13¿ are the same or different and each represents hydrogen or lower alkyl); R5 represents hydrogen or lower alkyl; R?6, R7 and R8¿ are the same or different and each represents hydrogen, lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, lower alkylthio, thiocyanato or halogeno; X represents CH or N; Y1-Y2 represents CH¿2?-O, CH3-S(O)n (wherein n is 0, 1 or 2), CH2CH2, CH=CH or CON(R?14¿) (wherein R14 represents hydrogen or lower alkyl): and Z represents oxygen or sulfur.</p> |