METHOD OF PREPARING THE ANTIPROCOAGULATING PREPARATION FROM MEDICINAL LEECH

摘要

FIELD: medicine, bioactive substances. SUBSTANCE: method involves leeches freezing, lyophilization and the following milling, dilution with water, acidification to pH = 5.8-7.0, heating on boiling water bath for 3-15 min followed by filtrate collection. Preparation shows antithrombic activity, prolongs plasma recalcification time, inhibits aggregation and adhesion of platelets due to the presence of leech prostaglandins. EFFECT: improved method of preparing, enhanced effectiveness. 1 tble