发明名称 |
ANTINEURODEGENERATIVE ERGOLINE DERIVATIVES |
摘要 |
The present invention provides the new use in the treatment of neurodegenerative diseases with ergoline derivatives of formula (I) wherein R1 represents a hydrogen atom or a linear or branched C1-C5 alkyl or C2-C5 alkenyl group optionally substituted with a C3-C7 cycloalkyl, a hydroxy group or a R3-substituted phenyl group wherein R3 is a hydroxy or a hydroxymethyl group; R2 represents a hydrogen atom or a linear or branched C1-C5 alkyl or a C2-C5 alkenyl group optionally substituted with a hydroxy group, or a R3-substituted phenyl group wherein R3 is as above defined, or with a C1-C5 alkoxy group; the symbols -- at positions 2,3 and 8, 9 independently denote a single or double chemical bond and Z represents a group (CH2)nOH, wherein n is 0 or an integer from 1 to 3, or a group C(R4)2OH wherein R4 is a C1-C5 alkyl or a phenyl group, or a pharmaceutically acceptable salt thereof. Some compounds of formula (I) are novel. Processes for their preparation and pharmaceutical compositions containing them are also described. |
申请公布号 |
WO9800424(A1) |
申请公布日期 |
1998.01.08 |
申请号 |
WO1997EP02955 |
申请日期 |
1997.05.29 |
申请人 |
PHARMACIA & UPJOHN S.P.A.;MANTEGANI, SERGIO;BRAMBILLA, ENZO;CARFAGNA, NICOLA;VARASI, MARIO |
发明人 |
MANTEGANI, SERGIO;BRAMBILLA, ENZO;CARFAGNA, NICOLA;VARASI, MARIO |
分类号 |
A61K31/48;C07D457/02;C07D457/10 |
主分类号 |
A61K31/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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