| 摘要 |
<p>Glutamic acid derivatives in which the amino group is substituted with a 2-amino-5,6,7,8-tetrahydropyrimido[4,5-b]azepin-6-yl)ethyl-Z-carbonyl group, in which Z is phenylene or thienediyl are inhibitors of glycinamide ribonucleotide formyltransferase and thus have use as antineoplastic agents. A typical embodiment is N-{4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrimido[4,5-b]azepin-6-yl)ethyl]-benzoyl}-L-glutamic acid.</p> |
