摘要 |
The present invention provides novel 5-(1-fluorovinyl)-1H-pyrimidine-2,4-dione derivatives of formula (I) which are useful as antineoplastic agents by themselves or in conjunctive therapy with the antineoplastic agent 5-fluorouracil. In said formula, R1 and R2 are each independently hydrogen, C1-C4 alkyl, or a phenyl group unsubstituted or substituted with from 1 to 3 substituents, wherein each substituent is selected from the group consisting of C1-C4 alkyl and C1-C4 alkoxy; and R3 is hydrogen, ribose, 2'-deoxyribose or arabinose. |
申请人 |
MERRELL DOW PHARMACEUTICALS INC., CINCINNATI, OHIO, US |
发明人 |
MCCARTHY, JAMES, R., SOLONA BEACH, CA 92075, US;MATTHEWS, DONALD, P., INDIANAPOLIS, IN 46250, US;SABOL, JEFFREY, S., LOVELAND, OH 45140, US |