| 摘要 |
<p>The invention relates generally to immunocontraceptive vaccine compositions comprising antigenic polypeptides having mammalian sp56 sperm protein antigenic determinants. The antigenic polypeptides can be synthetic polypeptides, fusion proteins and chimeric molecules. The vaccine is preferably administered to feral mammals in bait or feed formulations. Certain embodiments describe the use of species specific sequences of sp56. Also described are immunocontraceptive methods, antibodies immunoreactive with the sp56 antigenic determinants, and methods for screening for sperm fertility.</p> |
