| 摘要 |
A process for disinfecting protein solutions operates by flowing the solutions through a bed of iodinated organic polymer that acts as a gel filtration material. The preferred types of gel filtration material is Sephadex brand cross-linked dextrans, either G-25 or A-25 (DEAE modified Sephadex). The various types of cross-linked dextrans are readily iodinated before use by being mixed dry with elemental iodine at an elevated temperature such as 37 DEG C. Sephadex brand cross-linked dextrans can be readily iodinated to 50% weight of iodine to weight of dextrans or more. The preferred level of iodination is 30-40%. Before use the used it is first swelled in aqueous medium and then poured into a chromatographic column. Six ml of swelled 30% iodine Sephadex A-25 can effectively destroy virus in at least one liter of 5% human IgG. |
