NEW DIAGNOSTIC MARKER FOR SPLICING VARIETY OF GENE RELATED TO NEUROLOGICAL FUNCTION

摘要

PROBLEM TO BE SOLVED: To identify an individual subject to contraction of neurological diseases by detecting the presence of another splice site containing a specific sequence existing in a polyadenylated mRNAtransferred product or the like in a genetic specimen of an individual subject to contraction of neurological diseases. SOLUTION: A genetic specimen is prepared from an individual subject to contraction of neurological diseases including Alzheimer's disease; subsequently, the presence of another splice site containing an sequence VRXQ (V is valine; R is arginine; X is a hydrophobic amino acid residue; Q is glutamine) existing in a polyadenylated messenger RNA-transferred product or a protein coded thereby in the specimen is detected, thus identifying an individual subject to contraction of neurological diseases such as Alzheimer's disease by the subject diagnostic marker.