发明名称 |
Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers |
摘要 |
A method of preventing graft-versus-host disease in a patient being treated for relapsed or persistent leukemia. The method comprises administering to a host allogeneic T-cells genetically engineered to include a polynucleotide encoding a negative selective marker. Prior to the occurrence of graft-versus-host disease, an interaction or chemotherapeutic agent is administered to the host, which kills the genetically engineered T-cells, thereby preventing the occurrence of graft-versus-host disease. Such method also may be employed in connection with the treatment of any disease or disorder wherein the treatment includes bone marrow ablation followed by the administration of a T-cell depleted bone marrow transplant. |
申请公布号 |
AU3079697(A) |
申请公布日期 |
1998.01.05 |
申请号 |
AU19970030796 |
申请日期 |
1997.05.28 |
申请人 |
GENETIC THERAPY, INC. |
发明人 |
NIKHIL MUNSHI;DAVID L. ENNIST;WILLIAM F. JACOB;YAWEN L CHIANG |
分类号 |
A61K48/00;A61K31/00;A61K31/52;A61K31/522;A61K35/14;A61K35/26;A61K35/76;A61K38/00;A61K39/00;A61P35/00;A61P35/02;C12N15/08 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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