发明名称 |
Mutants of human interleukin-3 |
摘要 |
<p>Mutants of hIL-3 are provided having deletions covering virtually the complete coding region of hIL-3, while retaining their biological activity. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Another preferred group of mutants are substitution mutants. Some of these mutants have an antagonistic effect. Specific examples are Cys -> Ala mutants (Cys<1><6> -> Ala<1><6>, Cys<1><6>Cys<8><4> -> Ala<1><6>Ala<8><4>). Other mutants having an antagonistic effect are Glu<5><0> -> Lys<5><0> and Lys<7><9> -> Glu<7><9>. Finally antibodies are provided aimed at specific epitopes localized between amino acids 29 and 54.</p> |
申请公布号 |
GR3024679(T3) |
申请公布日期 |
1997.12.31 |
申请号 |
GR19970402325T |
申请日期 |
1997.09.10 |
申请人 |
GIST-BROCADES N.V. |
发明人 |
DORSSERS, LAMBERTUS CHRISTIAAN JOHANNES;VAN LEEN, ROBERT WILLEM |
分类号 |
C12N15/09;A61K38/00;A61K38/18;A61K38/19;A61K38/20;A61K39/395;A61P3/02;A61P7/00;A61P35/00;A61P37/00;A61P43/00;C07K;C07K14/00;C07K14/005;C07K14/195;C07K14/52;C07K14/53;C07K14/54;C07K16/00;C07K16/24;C12N;C12N1/21;C12N5/10;C12N15/24;C12N15/27;C12P21/02;C12P21/08;C12R1/07;C12R1/19;(IPC1-7):C12N15/27 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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