PROCESS FOR PREPARING INTERMEDIATES FOR THE SYNTHESIS OF ANTIFUNGAL AGENTS.

摘要

Disclosed is a process for preparing compounds of formula (I) wherein R is C1-C6 alkyl, comprising heating a mixture of a difluorobenzene derivative, allene, a dialkyl malonate of the formula CH2(CO2R)2, wherein R is C1-C6 alkyl, and a base, in a polar organic solvent in the presence of a catalyst, in a sealed vessel and the pressure within the vessel is 1 to 10 psig.