Berberine derivates for inhibiting production of HSP47

摘要

A pharmaceutical composition comprising a berberine derivative of the formula (I): wherein R<1> and R<2> are independently an alkyl group of 1 to 3 carbon atoms, or a pharmaceutically acceptable salt thereof, as a substance inhibiting HSP47 production, and a pharmaceutically acceptable carrier, is disclosed. The substance inhibiting HSP47 production can effectively improve the physiological conditions of a patient suffering from diseases exhibiting a pathosis of an overproduction of the extracellular matrix, and efficiently treat such diseases. Further, the substance is useful for preventing or treating various diseases accompanied by an abnormal growth of vascularization.