发明名称 |
Monoclonal antibodies to cachectin/tumor necrosis factor and methods for preparing same |
摘要 |
The present invention pertains to the novel hybridoma SDW18.1.1, hybridomas obtained from SDW18.1.1, monoclonal antibodies obtained from such hybridomas and derivatives of such monoclonal antibodies. The novel hybridomas are formed by fusion of cells from a mouse myeloma line and spleen cells from a mouse previously immunized with cachectin/TNF. Diagnostic and therapeutic utilities for the monoclonal antibodies and their derivatives are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.
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申请公布号 |
US5698419(A) |
申请公布日期 |
1997.12.16 |
申请号 |
US19950472910 |
申请日期 |
1995.06.07 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
WOLPE, STEPHEN D.;CERAMI, ANTHONY |
分类号 |
A61K38/00;A61K39/00;C07K14/47;C07K14/52;C07K14/525;C07K16/18;C07K16/24;C07K16/38;C12N5/0789;C12P1/00;C12P21/08;C12Q1/02;G01N33/53;(IPC1-7):C12P21/08;C12N5/12 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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