| 摘要 |
<p>The present invention relates to a PS1/429 nucleic acid, polypeptide, and derivatives thereof, comprising novel nucleotide and amino acid sequences. The invention also relates to methods of using such nucleic acids, polypeptides, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies to PS1/429, regulators of PS1/429 gene expression and activity, and methods of treating Alzheimer's disease. The invention especially relates to an isolated nucleic acid comprising a nucleotide sequence which hybridizes under stringent conditions to the nucleotide sequence set forth in SEQ ID NO:1, with the proviso that the nucleic acid does not contain all or part of the coding sequence for a polypeptide having 467 amino acids as set forth in SEQ ID NO:4 or SEQ ID NO:8. In addition, the invention includes an isolated nucleic acid comprising a PS1/429 unique nucleotide sequence and comprising nucleotides 206 and 207 as set forth in SEQ ID NO:1.</p> |
