发明名称 |
Treatment of hiv infection by interfering with host topoisomerase interaction with hiv gag and rt |
摘要 |
The present invention relates to therapeutic protocols and pharmaceutical compositions designed to target topo I for the treatment of HIV infection. The invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using human topo I and its interaction with HIV gag and RT as a target for intervention. The invention further relates to the use of human topo I to enhance the activity of RT. The present invention also relates to the expression of human topo I in transgenic animals, in particular mice, as a system to study the HIV life cycle and to screen agents for their ability to interfere with the HIV life cycle. |
申请公布号 |
AU3209797(A) |
申请公布日期 |
1997.12.09 |
申请号 |
AU19970032097 |
申请日期 |
1997.05.22 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
WILLIAM W. HALL;HIDEHIRO TAKAHASHI |
分类号 |
C12N15/09;A61K38/00;C12Q1/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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