发明名称 |
Pharmaceutical composition |
摘要 |
Polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising a polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate surfactants. Preferred polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, biologically active analogs of BPI, and biologically active variants of BPI.
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申请公布号 |
US5696090(A) |
申请公布日期 |
1997.12.09 |
申请号 |
US19950472995 |
申请日期 |
1995.06.07 |
申请人 |
XOMA CORPORATION |
发明人 |
MCGREGOR, WELDON COURTNEY;STUBSTAD, JAMES;CHANG, C. PAUL |
分类号 |
A61K47/34;A61K9/00;A61K38/00;A61K38/17;A61K47/10;A61K47/14;A61K47/26;A61P31/04;(IPC1-7):A61K35/14 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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