| 摘要 |
The present invention relates to the novel 7 alpha -(5-methylaminopentyl)-estratrienes of the general formula (I), in which R<2> is a hydrogen or fluorine atom, R<17> is a hydrogen atom, a methyl or ethynyl group, n is 2, 3 or 4, and x is 0, 1 or 2. The novel compounds are strong, pure anti-estrogenes and can be used to produce drugs to treat oestrogene-dependent diseases, for example, breast cancer, endometrial cancer, prostate hyperplasia, anovular infertility and melanoma.
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| 申请人 |
SCHERING AG, 13353 BERLIN, DE |
发明人 |
BITTLER, DIETER, 13503 BERLIN, DE;BOHLMANN, ROLF, DR., 14055 BERLIN, DE;HEINRICH, NIKOLAUS, DR., 12159 BERLIN, DE;KROLL, JORG, DIPL.-CHEM. DR., 12157 BERLIN, DE;SAUER, GERHARD, DR., 13465 BERLIN, DE;NISHINO, YUKISHIGE, DR., 14089 BERLIN, DE;PARCZYK, KARSTEN, DR., 12207 BERLIN, DE;SCHNEIDER, MARTIN, PROF. DR., 13469 BERLIN, DE;HEGELE-HARTUNG, CHRISTA, DR., 10179 BERLIN, DE;LICHTNER, ROSEMARIE, DR., 10823 BERLIN, DE |
