| 摘要 |
<p>The invention features tropane derivatives useable in particular for in vivo detection of dopamine transporters. These derivatives are of formula (I), in which R1 is I or Sn(R3)3, R2 is for instance the methyl group, and X and Y are various substituents. The derivatives with X = CH¿3? and Y = H present a high specificity for the dopamine transporter relative to that of serotonin (74 % inhibition when the transporter is previously saturated with GBR 12909)</p> |
