摘要 |
Selected compounds of formula (I) in which: R<1> is hydrogen or a corresponding pharmaceutically acceptable ester or a pharmaceutically acceptable salt thereof; R<2> and R<3> which may be the same or different is each selected from hydrogen or optionally substituted C(1-6)alkyl; X is a group X'(CH2)m in which X' is CO, CONR<4>, COO, CONR<4>CO, CONHO or CH2O in which R<4> is hydrogen or C(1-6)alkyl and m is 0 or an integer from 1 to 12; or a C(1-12)alkylene chain optionally interrupted by X'; and Y is an optionally substituted aryl group; having the absolute configuration (4R,SS); are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis. |