发明名称 |
Azabicyclic compounds useful as an intermediate for the preparation of pyidone carboxylic acid compounds and process for preparing the same |
摘要 |
Pyridone carboxylic acid compounds and pharmaceutically acceptable salts and physiologically hydrolyzable esters thereof are provided which are represented by the formula: <IMAGE> (I) wherein R1 is a lower alkyl, a halogen-substituted lower alkyl, a lower alkenyl, a cycloalkyl, or a substituted- or unsubstituted-phenyl group; R2 is a hydrogen atom, or a lower alkyl or an amino group; A is a nitrogen atom or the group C-X wherein X is a hydrogen or a halogen atom, or an alkoxy group; and Z is a group having the formula: <IMAGE> (IV) wherein n is 1 or 2; R3 and R4 each represent a hydrogen atom or a lower alkyl group, with proviso that, if n is 2, one of R3 and R4 is a hydrogen atom; R5 and R6 each represent a hydrogen atom, or a hydroxy, a lower alkoxy or an amino group which is unsubstituted or substituted by a lower alkyl group, with proviso that one of R5 and R6 is a hydrogen atom; and R7 is a hydrogen atom or a lower alkyl group. The compounds of the present invention show potent and broad spectrum of antibacterial activities.
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申请公布号 |
US5688965(A) |
申请公布日期 |
1997.11.18 |
申请号 |
US19960592171 |
申请日期 |
1996.01.26 |
申请人 |
CHEIL FOODS & CHEMICALS, INC. |
发明人 |
KIM, CHOONG SUP;KIM, JIN WOONG;LEE, JAE MOK;CHO, IL HWAN;YOUN, YONG SIK;SHIN, YOUNG JUN;LEE, KI HO;KIM, JE HAK;JUNG, YONG HWAN;AN, SEUNG HO |
分类号 |
C07D221/04;A61K31/4375;A61K31/44;A61K31/4427;A61K31/4439;A61K31/47;A61K31/4709;A61K31/472;A61K31/4725;A61K31/473;A61P31/04;C07D209/52;C07D401/04;C07D401/14;C07D471/04;(IPC1-7):C07D209/02;C07D209/04 |
主分类号 |
C07D221/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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