Process for the preparation of substituted thiopyran-1-oxides

摘要

PCT No. PCT/GB94/02332 Sec. 371 Date Apr. 24, 1996 Sec. 102(e) Date Apr. 24, 1996 PCT Filed Oct. 24, 1994 PCT Pub. No. WO95/11900 PCT Pub. Date May 4, 1995A process is described for the preparation of a compound of formula (IX) from 4-hydroxybutyl 3-pyridyl ketone. The compound of formula (IX) is an intermediate useful in the preparation of (1R,2R)-2-(3-pyridyl)-N-alkyl-tetrahydro-2H-thiopyran-2-carbothioamide 1-oxides which possess useful pharmaceutical properties, for example anti-hypertensive properties. <IMAGE> (IX)