发明名称 |
SULFONAMIDE-SUBSTITUTED CHROMANS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC, AND MEDICAMENT COMPRISING THEM |
摘要 |
Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I <IMG> I and of the formula 1 a <IMG> 1 a having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.
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申请公布号 |
CA2205477(A1) |
申请公布日期 |
1997.11.15 |
申请号 |
CA19972205477 |
申请日期 |
1997.05.15 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
HERLING, ANDREAS;GERLACH, UWE;BOHN, HELMUT;HROPOT, MAX;GREGER, RAINER;LANG, HANS JOCHEN;GOEGELEIN, HEINZ;ENGLERT, HEINRICH CHRISTIAN;BRENDEL, JOACHIM;BUSCH, ANDREAS |
分类号 |
A61K31/35;A61K31/352;A61K31/353;A61K31/44;A61K31/443;A61P1/00;A61P1/04;A61P9/00;A61P9/06;C07D311/68;C07D311/70;C07D311/72;C07D311/96;C07D405/12;(IPC1-7):C07D311/68;C07D409/12;C07D405/14;A61K31/38;A61K31/395 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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地址 |
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