发明名称 |
INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 AND METHODS FOR IDENTIFYING AND USING THE SAME |
摘要 |
A method of identifying inhibitors of glycogen synthase kinase-3 is provided. The method comprises providing a mixture comprising GSK-3, a phosphate source, and a GSK-3 substrate, incubating the mixture in the presence or absence of a test compound, and assessing the activity of GSK-3 in the mixture. A reduction of GSK-3 activity following incubation of the mixture in the presence of the test compound is an indication that the test compound is an inhibitor of GSK-3.
|
申请公布号 |
WO9741854(A1) |
申请公布日期 |
1997.11.13 |
申请号 |
WO1997US07238 |
申请日期 |
1997.04.30 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;PRESIDENTS AND FELLOWS OF HARVARD COLLEGE |
发明人 |
KLEIN, PETER, S.;MELTON, DOUGLAS |
分类号 |
A61K31/404;A61K38/00;A61K45/06;A61K49/00;C12N9/12;C12Q1/48;(IPC1-7):A61K31/40;A61K33/00;A61K38/28;A61K38/45;C07D491/12;C07K14/62;C12N9/99;C12Q1/68 |
主分类号 |
A61K31/404 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|