COMPOSITION COMPRISING A KATP CHANNEL INHIBITOR FOR USE IN THE TREATMENT OF HEMORRHAGIC SHOCK

摘要

This invention is directed to a pharmacologically acceptable composition for inhibiting or treating hemorrhagic shock in a mammal. The composition includes a KATP inhibitor and a pharmacologically acceptable carrier, with the KATP inhibitor being present in an amount sufficient to inhibit or treat hemorrhagic shock in the mammal. The invention is also directed to a method for inhibiting or treating hemorrhagic shock in a mammal. The method includes administering to the mammal an amount of a KATP channel inhibitor sufficient to inhibit or treat hemorrhagic shock in the mammal. In a preferred form of the invention, the KATP channel inhibitor is selected from the group consisting of sulfonylurea, a guanidine, a phenothiazine, an imidazoline, TMB8 (8-N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate, 2,3-butanedione monoxime, disopyramide, gliquidone, chlorpromazine, AMP-NPP, flecainide, MS551 and combinations thereof.