发明名称 THERAPEUTIC TREATMENT FOR VEGF RELATED OCCULAR DISEASES
摘要 A method for inhibiting VEGF stimulated endothelial cell growth, such as associated with macular degeneration, and VEGF stimulated capillary permeability, such as associated with macular edema are disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-¢N, N'-1,1'- ((2''-ethoxy)-3'''(O)-4'''-(N,N-dimethylamino)-butane)-bis-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dionehydrochloridesalt.
申请公布号 CA2253613(A1) 申请公布日期 1997.11.06
申请号 CA19972253613 申请日期 1997.05.01
申请人 ELI LILLY AND COMPANY 发明人 JIROUSEK, MICHAEL R.;KING, GEORGE L.;VIGNATI, LOUIS;WAYS, DOUGLAS KIRK;AIELLO, LLOYD P.
分类号 C07D487/22;A61K31/00;A61K31/40;A61K31/407;A61K41/00;A61K45/00;A61P9/00;A61P27/02;C07D498/22;(IPC1-7):A61K31/40;A61K31/395 主分类号 C07D487/22
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