| 发明名称 |
SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS. |
| 摘要 |
<p>Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C(1-8)alkyl; R3 is aryl or arylC(1-4)alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis.</p> |
| 申请公布号 |
MX9704736(A) |
申请公布日期 |
1997.10.31 |
| 申请号 |
MX19970004736 |
申请日期 |
1995.12.20 |
| 申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
DEIRDRE MARY BERNADETTE HICKEY;DASHYANT DHANAK;ROBERT JOHN IFE;DAVID GRAHAM TEW;COLIN ANDREW LEACH |
| 分类号 |
A61K31/395;A61K31/397;A61P3/06;A61P3/08;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P25/00;A61P29/00;A61P43/00;C07D205/09;(IPC1-7):C07D205/09 |
主分类号 |
A61K31/395 |
| 代理机构 |
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