| 发明名称 |
Stabilized solutions of platinum (II) antitumor agents. |
| 摘要 |
<p>Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.</p> |
| 申请公布号 |
GR3024340(T3) |
申请公布日期 |
1997.10.31 |
| 申请号 |
GR19970401986T |
申请日期 |
1997.07.31 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KAPLAN, MURRAY A.;PHUSANTI, LAWAN;PERRONE, ROBERT K.;STENBERG, SCOTT R.;AGHARKAR, SHEERAM;BOGARDUS, JOSEPH B. |
| 分类号 |
A61K9/08;A61K9/00;A61K31/28;A61K31/282;A61K31/555;A61K47/12;A61P35/00;(IPC1-7):A61K31/28 |
主分类号 |
A61K9/08 |
| 代理机构 |
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