| 摘要 |
<p>This invention provides liposomic composition, containing as active ingredient (-)-N-'alpha'-dimethyl-N-(2-propynylphenylethylamine) (selegilin) and/or salt thereof. This composition contains: 0.1-40 percent by weight of selegilin and/or a salt thereof, 2 to 40 percent by weight of lipids, preferably phospholipids, 0 to 10 percent by weight of cholesterol, 0 to 20 percent by weight of an alcohol, 0 to 25 percent by weight of a glycol, 0 to 3 percent by weight of an antioxidant, 0 to 3 percent by weight of a preserving agent, 0 to 2 percent by weight of a viscosity influencing agent, 0 to 50 percent by weight of cyclodextrin or a cyclodextrin derivative and 30 to 90 percent by weight of water. This invention relates to pharmaceutical composition, containin the liposomic composition described and if desired, usual filling and diluting agents and other auxiliaries, preferably in oral, parenteral or transdermal form. This invention provides the process for the preparation of liposomic compositions containing selegilin and/or salt thereof. Accordingly liposomic composition of this invention may be administered for the treatment of Alzheimer's disease, Parkinson's disease, depression, stroke, motion sickness or myelitis.</p> |
