| 摘要 |
<p>The invention relates to a process for the preparation of ortho-sulfocarboxylic acids of formula (I), which comprises: a) in a first reaction step, diazotising an aromatic ortho-aminosulfonic acid in the presence of an acid and nitrite in water, in an organic solvent or in a mixture thereof, to an ortho-diazonium sulfonate, and, b) in a second reaction step, reacting the ortho-diazonium sulfonate in the presence of a palladium catalyst in water, in an organic solvent or in a mixture thereof, with carbon monoxide, under overpressure, to an aromatic ortho-sulfocarboxylic acid. The invention also relates to a process for the preparation of sulfonylureas of formula (II) using ortho-sulfocarboxylic acids as intermediates.</p> |
