PHOSPHATE MIMICS

摘要

An analogue of a biologically active compound whose activity within a cell is regulated by phosphorylation of said compound, wherein said analogue comprises a di- or tri-phosphate mimic at the site of phosphorylation, said mimic being a moiety of formula (I) wherein X and Y, which may be the same or different, are fluorine or hydroxy, and Z represents an electron with drawing group or a pharmacologically acceptable salt thereof, are useful for treating a disease which is caused or exacerbated by a biologically active compound whose activity within a cell is regulated by phosphorylation of said compound.