| 摘要 |
<p>A process for the viral inactivation of lyophilized blood proteins, particularly Factor VIII, by heat comprising forming a stable complex between the blood protein and a cyclodextrin in an aqueous solution. The solution is then lyophilized and the blood protein/cyclodextrin complex is recovered. The lyophilized blood protein/cyclodextrin is then heated, e.g., to 80 °C for 72 hours, to inactivate any virus present. The material may then be reconstituted prior to administration to a patient.</p> |
