| 摘要 |
Therapeutic compositions, as well as methods for treatment of a disease that is characterized by defective chloride conduction across a cellular membrane, are disclosed. These compositions contain a polypeptide that has one or more of the following characteristics: 1) the ability to spontaneously form a channel in a lipid bilayer, 2) the ability to selectively transport chloride ions across that bilayer, and 3) the ability to dissolve in an aqueous physiological solution. These polypeptides include, but are not limited to, IC1n and porin molecules, such as aerolysin, cryptdin 2 and cryptdin 3.
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