发明名称 |
Growth hormone antagonists |
摘要 |
The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have growth inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist. Animals have been made which exhibited a reduced growth phenotype.
|
申请公布号 |
US5681809(A) |
申请公布日期 |
1997.10.28 |
申请号 |
US19940313505 |
申请日期 |
1994.09.26 |
申请人 |
OHIO UNIVERSITY |
发明人 |
KOPCHICK, JOHN J.;CHEN, WEN Y. |
分类号 |
A01K67/027;A61K38/00;C07K14/61;C12N15/85;(IPC1-7):C07K14/61 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|