发明名称 |
Alpha-substituted pyrimidine-thioalkyl and alkylether compounds. |
摘要 |
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I <CHEM> and pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds of Formula I where R4 is selected from the group consisting of -H or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R6 is selected from the group consisting of -H, or halo (preferably -CI); with the overall provisio that R4 and R6 are not both -H; The compounds of Formula IA are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. |
申请公布号 |
ZA9603281(B) |
申请公布日期 |
1997.10.24 |
申请号 |
ZA19960003281 |
申请日期 |
1996.04.24 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
RICHARD A. NUGENT;MICHAEL J. MURPHY;RICHARD C. THOMAS;GARY J. CLEEK;STEPHEN T. SCHLACHTER;JOEL MORRIS;DONN G. WISHKA;DAVID R. GRABER |
分类号 |
A61K31/505;A61K31/506;A61K31/535;A61P31/12;A61P31/18;C07D213/00;C07D239/00;C07D239/38;C07D239/46;C07D239/48;C07D239/56;C07D239/60;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D413/12;C07D471/04;C07D487/04;C07D491/04;C07D491/048 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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