发明名称 |
MESOTHELIUM ANTIGEN AND METHODS AND KITS FOR TARGETING IT |
摘要 |
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection. |
申请公布号 |
WO9725068(A3) |
申请公布日期 |
1997.10.23 |
申请号 |
WO1997US00224 |
申请日期 |
1997.01.03 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;PASTAN, IRA;CHANG, KAI |
发明人 |
PASTAN, IRA;CHANG, KAI |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K39/395;A61K45/00;A61K47/48;A61K49/00;A61K51/00;A61K51/10;A61P35/00;C07K14/195;C07K16/30;C07K19/00;C12N5/20;C12Q1/68;G01N33/15;G01N33/53;G01N33/574 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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