发明名称 |
Method for making a polypeptide derivative |
摘要 |
A method for making a homogeneous succinylated polypeptide is disclosed. The method can be carried out by adding a succinyl-containing compound to a polypeptide solution, followed by raising the pH of the polypeptide solution to a pH of between about pH 10 to pH 12.5. The succinylation reaction between the succinyl-containing compound and free amino groups of the polypeptide is essentially complete upon raising the polypeptide solution pH to the alkaline pH.
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申请公布号 |
US5677422(A) |
申请公布日期 |
1997.10.14 |
申请号 |
US19960701560 |
申请日期 |
1996.08.22 |
申请人 |
BECKMAN INSTRUMENTS, INC. |
发明人 |
SAFARIAN, ZARA;WANG, HANN-PING |
分类号 |
C07K1/107;(IPC1-7):C07K1/107 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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