| 发明名称 |
Monoclonal antibodies directed to the HER2 receptor |
| 摘要 |
Monoclonal antibodies which bind to the extracellular domain of the HER2 receptor and inhibit growth of SK-BR-3 breast tumor cells, which overexpress HER2, are disclosed. The monoclonal antibodies can be used for in vitro assays for detecting a tumor characterized by amplified expression of HER2.
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| 申请公布号 |
US5677171(A) |
申请公布日期 |
1997.10.14 |
| 申请号 |
US19940286303 |
申请日期 |
1994.08.05 |
| 申请人 |
GENENTECH, INC. |
发明人 |
HUDZIAK, ROBERT M.;SHEPARD, H. MICHAEL;ULLRICH, AXEL;FENDLY, BRIAN M. |
| 分类号 |
A61K31/00;A61K31/365;A61K31/366;A61K31/40;A61K31/407;A61K31/505;A61K31/519;A61K31/529;A61K31/70;A61K31/7008;A61K33/24;A61K38/00;A61K38/21;A61K39/395;A61K45/00;A61K47/48;A61P35/00;A61P43/00;C07K1/22;C07K14/00;C07K14/485;C07K14/495;C07K14/52;C07K14/525;C07K14/54;C07K14/545;C07K14/55;C07K14/555;C07K14/57;C07K14/705;C07K14/715;C07K16/00;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/91;G01N33/573;G01N33/574;G01N33/577;(IPC1-7):C07K16/00 |
主分类号 |
A61K31/00 |
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