| 摘要 |
<p>Constrained peptides comprising an amino acid sequence that consists of 30 amino acid residues or less are disclosed. The peptides comprise a human CD4 sequence within a cyclic portion and two exocyclic portions, which each comprises an aromatic amino acid residue, are disclosed. Pharmaceutical compositions comprising the peptide are disclosed. Methods of inhibiting the oligomerization of membrane bound CD4 in a CD4+ cell by contacting the cell with a peptide are disclosed. Methods of inhibiting activation of a T cell and methods of treating individuals with diseases, disorders and conditions whose causes and/or symptoms are associated with and/or characterized by T cell activation are disclosed.</p> |
