发明名称 |
PRECURSORS OF CATALYTIC ANTIBODIES |
摘要 |
The invention is directed to growth factors or precursors of catalytic antibodies comprising a B-cell surface molecule binding portion, which can induce B-cell mitogenesis. The preferred B-cell surface molecule binding portions are the immunoglobulin binding molecules of protein L from peptostreptococcus magnus, protein A, protein G and protein H. The growth factor having an ability to induce B-cell mitogenesis can be further linked to a target antigen to which catalytic antibodies are sought. B-cell mitogenesis is then dependent on the catalytic cleavage of the antigen portion of the growth factor by catalytic antibodies on the surface of B cells. The method of the present invention is useful for generating catalytic antibodies for both therapeutic and diagnostic purposes. |
申请公布号 |
CA2249455(A1) |
申请公布日期 |
1997.10.02 |
申请号 |
CA19972249455 |
申请日期 |
1997.03.26 |
申请人 |
AMRAD OPERATIONS PTY. LTD. |
发明人 |
SUESS, GABRIELE MARIA;TREUTLEIN, HERBERT RUDOLF;TARLINTON, DAVID MATHEW;KOENTGEN, FRANK |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/21;A61K38/22;A61K38/46;A61K39/00;A61K39/395;A61P37/00;A61P37/04;A61P43/00;C07K14/47;C07K14/475;C07K16/28;C07K16/42;C07K19/00;C12N9/00;C12N15/32;(IPC1-7):C12N15/62;C07K16/00;C12N15/13;C07K14/195;C12N15/31;C12N9/36;A61K39/385;A61K39/39;A61K39/44;C12N9/96 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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