发明名称 |
Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability |
摘要 |
Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing 3-(2'-hydroxy-4',6'-dimethyl phenyl)-3,3-dimethyl propionic acid and its deriveatives and acyloxyalkoxy linkers. Also provided are pharmaceutical compositions containing effective amounts of these cyclic prodrugs in combination with pharmaceutically acceptable carriers, excipients, or diluents.
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申请公布号 |
US5672584(A) |
申请公布日期 |
1997.09.30 |
申请号 |
US19950429732 |
申请日期 |
1995.04.25 |
申请人 |
THE UNIVERSITY OF KANSAS |
发明人 |
BORCHARDT, RONALD T.;SIAHAAN, TERUNA;GANGWAR, SANJEEV;STELLA, VALENTINO J.;WANG, BINGHE |
分类号 |
A61K38/00;A61P5/00;A61P7/08;A61P9/00;A61P25/00;A61P25/20;A61P31/12;A61P35/00;C07K1/107;C07K5/107;C07K7/06;C07K14/665;C07K14/70;(IPC1-7):A61K38/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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