9-aminoacridine derivatives possessing psychotropic, antiamnestic and lipid-regulative activity

摘要

"Derivatives of 9-aminoacridine characterized by psychothropic, antiamnestic and lipid-regulating activities". New chemical compounds derived of 9-aminoacridine with a general formula are presented: CH3 R3=-C1-C5 alkyl phenylmethyl, substituted phenylmethyl or diethylaminoethyl X=C=O, or CHOH, Y=CH2 or X+Y=CH=CH and their salts with organic and inorganic acids. The target compounds were obtained by a reaction of substituted nitriles of anthranilic acid with dimedone and subsequent cyclization of intermediate enaminonitriles to the corresponding 9-amino-3,4-dihydroacridine-1(2H)-ones. The reduction of the compounds or their alkylated or aralkylated at 9-aminogroupe derivatives results in corresponding alkanols, which on dehydratation give 9-amino-3,4-dihydroacridines. In animal experiments the derivatives of 9-aminoacridine in question showed psychothropic, antiamnestic and lipid-regulating activities and less toxicity as compared with known reference drugs.