| 摘要 |
Compounds of general formula (I) wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, and R<8> each independently are: hydrogen; halogen; nitro; nitroso; cyano; a group -CO-Z-R<10>, -CS-Z-R<10>, -SO2-Z-R<10?, -C(NH)-NR?10>R<11>, -CO-R<10>, -SO-R<10>, -SO2-R<10>, -Z-CO-R<10>, -Z-CO-Z-R<10>, -Z-CS-R<10> or -Z-SO2-R<10>, -O-R<10>, -S-R<10> or -NR<10>R<11>, wherein each Z independently is -O-, -S- or -N(R<11>)-; optionally substituted, linear or branched C1-10alkyl, C2-10alkenyl, C4-10alkadienyl, C6-10alkatrienyl, C2-10alkynyl, C3-8cycloalkyl, C3-8cycloalkenyl, C4-8cycloalkadienyl, C6-8cycloalkatrienyl or C3-8cycloalkyl-C1-4alkyl; or R<3> and R<7>, and/or R<4> and R<8> together form a bond; or R<1> and R<2>, and/or R<5> and R<6> together form a bivalent group -(CH2)n- wherein n is an integer from 3 to 5, or a bivalent group -Z-(C(R<15>)2)m-Z- wherein m is an integer from 1 to 3; X<1> and X<2> each independently is O, S, or N(R<12>); and Y<1> and Y<2> each independently is N or C(R<13>); with the proviso that when X<1>-Y<1> and X<2>-Y<2> are both O-N, and R<3> and R<7>, and R<4> and R<8>, each together form a bond, then at least one of R<1>, R<2>, R<5>, and R<6> is different from hydrogen, or that R<1> and R<6> are both different from nitro, methyl and unsubstituted phenyl; and physiologically acceptable salts thereof. Such compounds have anti-cancer properties.
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