| 摘要 |
<p>A compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein, Ro represents an aryl group optionally substituted with one, two or three substituents selected from the list consisting of: hydroxy, hydroxymethyl, nitro, amino, alkylamino, dialkylamino, alkylsulphonamido wherein the alkyl group is optionally substituted with one, two or three substituents selected from: halogen, haloalkyl, hydroxy, alkoxy, or arylsulphonamido wherein the aryl group is optionally substituted, providing that Ro is not 3-methylsulphonylaminophenyl when X represents O or S; R?1 and R1a¿ each independently represent hydrogen or an alkyl group; R2 represents a moiety of formula (a), wherein R?4 and R5¿ each independently represents hydrogen, alkyl, cycloalkyl, aryl or aralkyl or R5 together with R4 represent -(CH¿2?)n- wherein n is 3, 4 or 5; and R?3¿ represents hydrogen, halogen, alkyl or alkoxy; a pharmaceutical composition comprising such a compound, a process for preparing such a compound and the use of such a compound and composition in medicine.</p> |
