发明名称 |
Methods for optimizing fluoropyrimidine cancer therapy |
摘要 |
The present invention provides a method of predicting whether an individual will be intolerant to the effect of fluoropyrimidines comprising the step of measuring the activity of orotate phosphoribosyltransferase activity in a biological sample obtained from said individual. Also provided is a method of determining a non-toxic dose of 5-fluoruracil in an individual in need of fluoropyrimidine therapy, comprising the step of measuring the activity of 5-fluoruracil phosphoribosyltransferase (FUPRTase) in a biological sample obtained from said individual.
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申请公布号 |
US5670331(A) |
申请公布日期 |
1997.09.23 |
申请号 |
US19950493237 |
申请日期 |
1995.06.22 |
申请人 |
THE UNIVERSITY OF ALABAMA RESEARCH FOUNDATION |
发明人 |
EL KOUNI, MAHMOUD H.;NAGUIB, FARDOS N. M. |
分类号 |
C12Q1/48;(IPC1-7):C12Q1/48 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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